Glossary of Medical Terms

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PARTIAL THROMBOPLASTIN TIME

Test of the intrinsic (factors viii, ix, xi, and xii) and general (fibrinogen, prothrombin, factors v and x) pathways of coagulation in which a mixture of plasma and phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides) is recalcified and the time required for the appearance of fibrin strands measured. Activation may be provided by contact with the glass pipe or exposure to activators (e.g., ellagic acid, particulate silicates such as diatomaceous land or kaolin) till addition of the calcium chloride. It is used as a screening test and to monitor heparin therapy.
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