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ACUTE MONOCYTIC LEUKAEMIA
The most generaltranslocation in this mess of poorly differentiated monocytic cells involves chromosomeregion 11q in a big percentage of cases.
The translocation involves a cellular oncogene, c-ets which is mapped to the 11q23-24 region. The most general translocations reported are t(6;11), t(9;11), t(11;17) and t(11;19), of which t(9;11) (p21-22;q23) is by far the most frequently detected and implicated in acute myeloid leukaemia. The cellsexpressCD14 surface antigen, which is diagnostic of monocytic cells.
Acronym: AML
Classification: FAB M5