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BUTHIONINE SULFOXIMINE
A synthetic amino acid that depletes glutathione by irreversibly prohibition gamma-glutamylcysteine synthetase. Inhibition of thisenzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibitmacrophage activation.
Pharmacological action: antimetabolites, antimetabolites, antineoplastic, enzyme inhibitors, radiation-protective agents, radiation-sensitizing agents.
Chemical name: Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-