Glossary of Medical Terms

Our online medical glossary of medical terms and definitions includes definitions for terms related to treatment, and general medicine

DIDANOSINE

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the consummation of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddi is then metabolised to dideoxyadenosine triphosphate, its putative active metabolite. Pharmacological action: anti-HIV agents, antimetabolites, reverse transcriptase inhibitors. Chemical name: Inosine, 2',3'-dideoxy-
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