Glossary of Medical Terms

Our online medical glossary of medical terms and definitions includes definitions for terms related to treatment, and general medicine

HGF

Polypeptide mitogen originally shown to reason cell division in hepatocytes. In the liver, the main sources of hepatocyte growth factor are nonparenchymal cells. It is now clear that hepatocyte growth factor is a mitogen for a number of cell types and it is found in much cells external the liver, including platelets. Hepatocyte growth factor is synthesised as a single chain precursor that is proteolytically cleaved to give a hard chain (70 kD) and a easy chain (30 kD) linked by a single disulphide bond. It contains multiple copies of the kringle domain. However, both the single chain precursor and the two chain forms of hepatocyte growth factor are biologically active and hepatocyte growth factor is usually isolated as a mixture of the two forms. Hepatocyte growth factor also alters cell motility and is now known to be selfsame to scatter factor. Acronym: HGF This entry appears with alow from the Vocabulary of Cell and Molecular Biology
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