Glossary of Medical Terms

Our online medical glossary of medical terms and definitions includes definitions for terms related to treatment, and general medicine

OVERLAP INDEX

A measure of the extent to which a population of cells in culture forms multilayers. The predicted amount of overlapping is calculated knowing the cell density, the projected area of the nucleus (usually) and assuming a Poisson distribution. The actual overlap is measured on fixed and stained preparations and the ratio of actual/predicted is derived. A value of 1 implies a random distribution with no constraint on overlapping, usual fibroblasts may have values as low as 0.05. Although a useful measure it does not unambiguously indicate the cause for the effect, which may be contact inhibition of locomotion or differential adhesion of cells between substratum and another cells. This entry appears with alow from the Vocabulary of Cell and Molecular Biology
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