Glossary of Medical Terms

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PANENCEPHALITIS

A diffuse inflammation of the brain. Nodular panencephalitis, perhaps a form of subacute sclerosing panencephalitis. Synonym: Pette-Doring disease. Subacute sclerosing panencephalitis (SSPE), a rare chronic, progressive encephalitis that affects primarily children and young adults, caused by the measles virus. Characterised by a history of primary measles infection till the age of two years, followed by different asymptomatic years, and then gradual, progressive psychoneurological deterioration, consisting of personality change, seizures, myoclonus, ataxia, photosensitivity, ocular abnormalities, spasticity, and coma. Quality periodic activity is seen on EEG; pathologically, the white matter of both the hemispheres and brainstem are affected, as well as the cerebral cortex, and eosinophilic involving bodies are gift in the cytoplasm nuclei of neurons and glial cells. Death generally occurs within three years. Synonym: Bosin's malady, Dawson's encephalitis, involving body encephalitis, sclerosing leukoencephalitis, subacute involving body encephalitis, subacute sclerosing leukoencephalitis, van Bogaert encephalitis.
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