Immunosuppressive
macrolide antibiotic with structural similarity to FK506, inhibits T and
B-cell proliferation
but at a
many later
stage than FK506, despite
binding to the
same immunophilin. Inhibits TOR (target of rapamycin) in the Ras/MAP
kinase signalling pathway.
This
entry appears with alow from the Vocabulary of Cell and Molecular Biology