Glossary of Medical Terms

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THYROID HORMONE RESISTANCE SYNDROME

An inherited syndrome of peripheral resistance to thyroid hormones, transmitted as an autosomal recessive trait, characterised by heighten serum concentrations of thyroxine and triiodothyronine, heighten thyroid hormone binding ratio, and usual to slightly heighten thyroid-stimulating hormone and its response to thyrotropin-releasing hormone. The affected persons are euthyroid to slightly hypothyroid. The absence of hypermetabolism and the presence of possible hypothyroidism indicate the subsistence of partial resistance to the peripheral action of thyroid hormone.
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